Glutathione and mitochondria
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چکیده
منابع مشابه
Glutathione and mitochondria
Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including mitochondria where its concentration in the mat...
متن کاملThe Reduction and Oxidation of Glutathione by Plant Mitochondria.
is catalyzed by glutathione reductase (3, 4, 5). In earlier studies this reaction has been coupled with soluble dehydrogenases which utilize TPN as a coenzyme (6). Since tissue fractionation studies have shown that numerous dehydrogenases, including those associated with the oxidation of the Krebs cycle intermediates, are localized within the mitochondrion, it was of interest to determine wheth...
متن کاملDual Targeting of Glutathione Reductase to Mitochondria and Chloroplasts
..................................................................................................................................... 4 List of Publications for the thesis............................................................................................. 5 Abbreviations .......................................................................................................................
متن کاملAzidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization.
Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various diseases and chemotherapies. This study analyzed azidothymidine (AZT)-caused failures in mitochondrial functions, in redox regulation and activation of the HIV-1 gene expression. We monitored intracellular concentrations of ATP and glutathione (GSH) as the indicators of e...
متن کاملRedox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria.
AIMS We have previously shown that exercise leads to sustainable cardioprotection through a mechanism involving improved glutathione replenishment. This study was conducted to determine if redox-dependent modifications in glutathione reductase (GR) were involved in exercise cardioprotection. Furthermore, we sought to determine if reactive oxygen species generated by NADPH oxidase and/or mitocho...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2014
ISSN: 1663-9812
DOI: 10.3389/fphar.2014.00151